Ekonomické hodnocení léčby fibrilace síní radiofrekvenční katétrovou ablací

The thesis is focused on the economical evaluation of invasive treatment of atrial fibrillation using radiofrequency catheter ablation in comparison with standard pharmacological therapy. Two groups of patients treated with these methods were studied retrospectively. Effectiveness, number of complications, costs and benefits of pharmacological versus invasive therapy were evaluated. Based on the retrieved data, economical analysis grounded on the cost effectiveness analysis and cost utility analysis was performed. Results were validated using sensitivity analysis and subjected to a thorough discussion. Catheter ablation of persistent atrial fibrillation is more effective but more costly method of treatment compared to the standard pharmacological therapy. Incremental costs per QALY were calculated as 235 104 CZK per case, which makes catheter ablation therapy of atrial fibrillation feasible, more effective and therefore preferred method compared to standard pharmacological therapy, since this number lays well below the threshold of willingness to pay for the specific treatment method, which is 1 000 000 CZK in the Czech Republic. Therefore, catheter ablation treatment of persistent atrial fibrillation seems cost effective intervention compared to conventional pharmacological therapy.